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For readers comparing GLP-1 options and side-effect profiles, our tirzepatide side effects guide explains what to expect and how nausea can differ across treatment plans

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The following year, antagonism of the GIP receptor by palmitoylation of GIP analogues with N- and C-terminal modifications reduced body weight and improved metabolic control in high-fat-fed mice

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Metformin reduced cardiovascular events in new-onset diabetes patients with obesity in the UK Prospective Diabetes Study (UKPDS 34) [25], but not in DPP/DPPOS [26], and some meta-analyses have shown controversial results [27, 28]

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